Onglyza And Kombiglyze XR Lawsuits

Onglyza And Kombiglyze XR Lawsuits

Nearly 30 million Americans have Type 2 diabetes, a condition that carries life-altering ramifications if not properly controlled. Pharmaceutical companies have cashed in on this growing epidemic with the introduction of several new diabetes drugs, such as AstraZeneca’s Onglyza and Kombiglyze XR.

Along with GLP-1 class treatments like Byetta, DPP-4 inhibitors like Onglyza and Kombiglyze XR have sparked safety concerns in regards to potential health complications like heart failure, pancreatitis, pancreatic cancer and thyroid cancer..

Side effects of Onglyza & Kombiglyze XR 

Some of the most common side effects of Onglyza and Kombiglyze XR include:

  • Headaches
  • Urinary tract infections
  • Upper respiratory tract infections
  • Nausea
  • Fatigue
  • Swelling or fluid retention

The following are more severe side effects linked to saxagliptin:

  • Pancreatitis (swelling of the pancreas)
  • Severe and persistent joint pain
  • Difficulty swallowing or breathing
  • Development of pre-cancerous cells
  • Pancreatic abnormalities
  • Increased risk for heart failure

Heart failure, also called congestive heart failure, is characterized by extreme fatigue, irregular heart rate, confusion and shortness of breath caused by a weakened heart muscle that is unable to sufficiently pump blood throughout the body. Depending on the extent of the damaged heart muscle, treatment may entail lifestyle changes, prescription medications, ventricular assist devices and surgery.

After reviewing the SAVOR clinical data, which included the cardiovascular outcomes of more than 16,000 diabetic patients taking either a placebo or Onglyza, an FDA advisory panel recommended that that AstraZeneca include a warning regarding heart failure risks on Onglyza and Kombiglyze XR labels. One FDA panel member even recommended pulling Onglyza off the market entirely, though this measure was never implemented.

Damages available to Onglyza & Kombiglyze XR claimants

  • Past, present and future medical expenses
  • Loss of income
  • Reduced earning potential
  • Emotional trauma
  • Wrongful death and funeral expenses
  • Loss of consortium
  • Punitive damages

Initiating litigation is no guarantee of success, but if you or a family member has suffered health complications or heart failure after taking Onglyza, our lawyers can assess the merits and potential worth of your dangerous drug lawsuit during a free case evaluation.

Questions about filing a drug injury lawsuit?

Over the past five years, The Sanders Firm has procured more than $200 million in settlements and verdicts on behalf of our clients. Put our vast experience and perseverance to work for you and your family.

To learn more about filing a Kombiglyze XR or Onglyza lawsuit, call 1-800-FAIR-PLAY to schedule a confidential consultation.

Allegations raised in lawsuits

Onglyza, like other diabetes medications, was designed to improve the health and lives of patients. Unfortunately, the potential risks of saxagliptin may outweigh benefits, given the life-threatening nature of heart failure and cancer.

Those who suffered complications after taking Onglyza or Kombiglyze XR may claim that AstraZeneca:

  • Failed to conduct sufficient pre-market trials
  • Failed to adequately warn patients and their health care providers about possible side effects
  • Fraudulently or negligently marketed their medication
  • Marketed their product despite having knowledge of inherent dangers

With the guidance and representation of a knowledgeable drug injury attorney, plaintiffs may be able to recover substantial compensation by bringing a personal injury lawsuit against AstraZeneca.

Onglyza & Kombiglyze XR heart risks

In fact, patients who take Onglyza (saxagliptin) to control their blood glucose levels are at a greater risk of being hospitalized for heart failure, according to the FDA. Health regulators recently analyzed the preliminary findings of the SAVOR clinical trial to better determine cardiovascular risks associated with saxagliptin. Beyond a 27 percent increase in heart failure risk, FDA officials also acknowledged a rise in the rate of “all-cause mortality” among study participants who took Onglyza or Kombiglyze XR.

The Sanders Firm is nationally renowned in the arena of pharmaceutical litigation. Our veteran product liability lawyers are currently reviewing Onglyza and Kombiglyze XR lawsuits with patients who suspect their health concerns are linked to a defective or inherently dangerous diabetes drug. The law affords legal remedies for individuals who have been injured by a product that was sold with insufficient warnings or was not properly tested prior to launch. Drug manufacturers may be held liable for damages in the event patients experienced side effects such as heart failure, cardiovascular problems or the development of cancerous tumors after using Onglyza as instructed.

Incretin mimetics and cancer risks

The FDA continues to explore the health risks of incretin mimetic drugs such as Onglyza, which researchers have also linked to pancreatic abnormalities, inflammation and the development of pre-cancerous cells in Type 2 diabetics. In 2013, the medical journal Diabetes published a study in which researchers identified precancerous cellular changes in the pancreatic tissue of patients who had taken mimetic drugs to manage their Type 2 diabetes.

The results weren’t sufficient to demonstrate a definitive link between Onglyza and pancreatic cancer, but U.S. health regulators did issue a drug safety communication on the topic and announced their intentions to further investigate “pancreatic toxicity associated with the incretin mimetics.”

At The Sanders Law Firm, Success Is A Tradition

Founded in 1967, The Sanders Law Firm has flourished into one of New York’s most successful personal injury practices, with an accomplished team of attorneys, paralegals, health care consultants, and support staff. Our trial attorneys take new cases on a contingency basis, which means there is no cost to the client unless we secure monetary damages on your behalf.

Our personal injury law firm continues to make its industry-leading legal services even better, and hire attorneys and staff that enable us to serve a more diverse population.

At The Sanders Firm, there is never any charge to evaluate your case. We have helped thousands of injured clients throughout New York City, Long Island, Brooklyn, Bronx, Queens, and Staten Island, and we’re prepared to help you too. In just the last five years we have procured over $100 million dollars on behalf of our clients, thanks to our vast resources and experienced attorneys. Our personal injury law firm continues to make its industry-leading legal services even better, and hire attorneys and staff that enable us to serve a more diverse population.

To set up your free, no-obligation case review with a New York personal injury lawyer, please call (516) 591-3208 or contact us using our online form. Our friendly staff is standing by to take your call 24 hours a day, 7 days a week.



The Sanders Law Firm is a New York personal injury practice with offices in Long Island, Manhattan, Queens, and Brooklyn.